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KMID : 1161420210240040377
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Journal of Medicinal Food
2021 Volume.24 No. 4 p.377 ~ p.384
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Role of Anti-Inflammatory, Reactive Oxygen Species Scavenging Activity and Nematicidal Properties of Myrtle Berry Seeds on Helminthiasis Treatment
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Jabri Mohamed-Amine
Hajaji Soumaya
Rtibi Kais
Sebai Hichem
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Abstract
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This study was undertaken to investigate the involvement of the reactive oxygen species (ROS) and proinflammatory cytokine production in the pathogenicity of gastrointestinal nematode Heligmosomoides polygyrus in mice and also the protective effect of myrtle (Myrtus communis L.) berry seeds aqueous extract (MBSAE). With this aim, Swiss Albino mice were divided into four groups of 10 animals each: control, helminthiasis, helminthiasis + MBSAE, and helminthiasis + Albendazole. The animals were infected with infective third larval stage (L3) of H. polygyrus by oral administration. Mice were treated with bidistilled water, MBSAE (100?mg/kg, b.w., p.o.) or Albendazole (100?mg/kg, b.w., p.o.). We have demonstrated that MBSAE (100?mg/kg, b.w., p.o.) significantly reduced the total mean adult worms compared with the infected and nontreated group. Moreover, hematological parameters, intestinal ROS such as hydrogen peroxide (H2O2), hydroxyl radical (OH?), and superoxide anion (O2??), as well as serum cytokines such as interleukin (IL)-1β and IL-6 were analyzed. We have shown that H. polygyrus infection has disrupted all these biochemical parameters and that MBSAE treatment has significantly corrected these disturbances. The effect of plant extract was comparable to the standard drug albendazole. Therefore, MBSAE appeared to be a promising agent for the control of intestinal helminthiasis.
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KEYWORD
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cytokines, H. polygyrus, hematological parameters, Myrtus communis, reactive oxygen species
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